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Article

Evolution in the influenza A H3 stalk - a challenge for broad-spectrum vaccines?

The Journal of general virology - 1 Feb 2014

Lees William D, Moss David S, Shepherd Adrian J

Abstract excerpt

Recently, a number of broad-spectrum human antibodies binding to the stalk region of influenza A haemagglutinin (HA) have been isolated. As this region tends to develop substitutions at a slower rate than other regions of HA, a vaccine eliciting such antibodies could have a longer effective life. But this begs a question: is the stalk resistant to change even in the face of evolutionary pressure? In this paper,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemagglutinin Glycoproteins, Influenza Virus

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Source

Identifiers

PMID: 24187015
DOI: 10.1099/vir.0.059410-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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