Article

Evaluating the efficacy of vatiquinone in preclinical models of mitochondrial disease

2024-06-03

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Genetic mitochondrial diseases are a major challenge in modern medicine, impacting around 1:4,000 individuals. Leigh syndrome is the most common pediatric presentation of mitochondrial disease. There are currently no effective clinical treatments for mitochondrial disease. In humans, patients are often treated with antioxidants, vitamins, and strategies targeting...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6054b5ef-6728-5782-87c5-06d906e4a579
DOI: 10.21203/rs.3.rs-4202689/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evaluating the efficacy of vatiquinone in preclinical models of mitochondrial diseaseDOI 10.21203/rs.3.rs-4202689/v1Read

Management of Leigh syndrome: Current status and new insights.Semantic proximity Read

Hypoxia as a therapy for mitochondrial diseaseSemantic proximity Read

Maltodextrin administration ameliorates brain pathology in a mouse model of mitochondrial diseaseSemantic proximity Read

Use of Elamipretide in Patients Assigned Treatment in the Compassionate Use Program: Case Series in Four Rare Orphan DiseasesSemantic proximity Read

Targeted Therapies for Leigh Syndrome: Systematic Review and Steps Towards a 'Treatabolome'.Semantic proximity Read

Moving towards clinical trials for mitochondrial diseases.Semantic proximity Read

Strategies for the modulation of mitochondrial metabolism and activity in the treatment of neurodegenerative diseases: A systematic review and meta-analysisSemantic proximity Read

Mitochondria-targeted senotherapeutic interventionsSemantic proximity Read

Targeting the human thioredoxin system by diverse strategies to treat cancer and other pathologies.Semantic proximity Read

Discovery of a pyrazolopyridine alkaloid that mitigates neuronal ER stress and age-related declineSemantic proximity Read

Mitigation of NADH: ubiquinone oxidoreductase deficiency by chronic Trolox treatment.Semantic proximity Read

Mitochondrial Respiratory Chain Function is crucial for Muscle Toxicity in Facioscapulohumeral Muscular DystrophySemantic proximity Read