Article
Hippo pathway-related genes expression is deregulated in myeloproliferative neoplasms.
Medical oncology (Northwood, London, England) - 23 May 2022
Cacemiro Maira da Costa, Cominal Juçara Gastaldi, Pereira Luiz Miguel, Berzoti-Coelho Maria Gabriela, Berbel Giovana Michelassi, Baroni Luciana, Malta Tathiane, Tognon Raquel, Nunes Natalia de Souza, Souto Elizabeth Xisto, de Figueiredo-Pontes Lorena Lobo, Yatsuda Ana Patricia, de Castro Fabíola Attié
Abstract excerpt
Myeloproliferative neoplasms (MPN) are hematological disorders characterized by increased proliferation of precursor and mature myeloid cells. MPN patients may present driver mutations in JAK2, MPL, and CALR genes, which are essential to describe the molecular mechanisms of MPN pathogenesis. Despite all the new knowledge on MPN pathogenesis, many questions remain to be answered to develop effective therapies to...
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