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Article

Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations.

Nature communications - 10 Jan 2012

Eizaguirre Christophe, Lenz Tobias L, Kalbe Martin, Milinski Manfred

Abstract excerpt

The genes of the major histocompatibility complex are the most polymorphic genes in vertebrates, with more than 1,000 alleles described in human populations. How this polymorphism is maintained, however, remains an evolutionary puzzle. Major histocompatibility complex genes have a crucial function in the adaptive immune system by presenting parasite-derived antigens to T lymphocytes. Because of this function,...

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Identifiers

PMID: 22233631
DOI: 10.1038/ncomms1632
PMCID: PMC3272583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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