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Major <scp>H</scp>istocompatibility <scp>C</scp>omplex class <scp>II</scp>b polymorphism influences gut microbiota composition and diversity

27 Jun 2014

Abstract excerpt

Animals harbour diverse communities of symbiotic bacteria, which differ dramatically among host individuals. This heterogeneity poses an immunological challenge: distinguishing between mutualistic and pathogenic members of diverse and host-specific microbial communities. We propose that Major Histocompatibility class II (MHC) genotypes contribute to recognition and regulation of gut microbes, and thus, MHC...

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PMID: 24975397
DOI: 10.1111/mec.12846

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