Article
Positive selection drives the evolution of a major histocompatibility complex gene in an endangered Mexican salamander species complex.
Immunogenetics - 1 Jun 2015
Tracy Karen E, Kiemnec-Tyburczy Karen M, DeWoody J Andrew, Parra-Olea Gabriela, Zamudio Kelly R
Abstract excerpt
Immune gene evolution can be critical to species survival in the face of infectious disease. In particular, polymorphism in the genes of the major histocompatibility complex (MHC) helps vertebrates combat novel and diverse pathogens by increasing the number of pathogen-derived proteins that can initiate the host's acquired immune response. In this study, we used a combination of presumably adaptive and neutral...
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