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Article

Global DNA methylation differences involving germline structural variation impact gene expression in pediatric brain tumors.

Nature communications - 21 May 2025

Chen Fengju, Zhang Yiqun, Li Wei, Sedlazeck Fritz J, Shen Lanlan, Creighton Chad J

Abstract excerpt

The extent of genetic variation and its influence on gene expression across multiple tissue and cellular contexts is still being characterized, with germline Structural Variants (SVs) being historically understudied. DNA methylation also represents a component of normal germline variation across individuals. Here, we combine germline SVs (by short-read sequencing) with tumor DNA methylation across 1292 pediatric...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40399292
DOI: 10.1038/s41467-025-60110-y
PMCID: PMC12095544

Genes

MSH2
PALB2
POLD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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