Article
Destabilization of the epidermal growth factor receptor (EGFR) by a peptide that inhibits EGFR binding to heat shock protein 90 and receptor dimerization.
The Journal of biological chemistry - 13 Sept 2013
Ahsan Aarif, Ray Dipankar, Ramanand Susmita G, Hegde Ashok, Whitehead Christopher, Rehemtulla Alnawaz, Morishima Yoshihiro, Pratt William B, Osawa Yoichi, Lawrence Theodore S, Nyati Mukesh K
Abstract excerpt
An eight-amino acid segment is known to be responsible for the marked difference in the rates of degradation of the EGF receptor (ErbB1) and ErbB2 upon treatment of cells with the Hsp90 inhibitor geldanamycin. We have scrambled the first six amino acids of this segment of the EGF receptor (EGFR), which lies in close association with the ATP binding cleft and the dimerization face. Scrambling these six amino acids...
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