Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array.

doi:10.1038/ejhg.2015.63

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Article

Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array.

European journal of human genetics : EJHG - 1 Jan 2016

Rodriguez Santiago, Gaunt Tom R, Guo Yiran, Zheng Jie, Barnes Michael R, Tang Weihang, Danish Fazal, Johnson Andrew, Castillo Berta A, Li Yun R, Hakonarson Hakon, Buxbaum Sarah G, Palmer Tom, Tsai Michael Y, Lange Leslie A, Ebrahim Shah, Davey Smith George, Lawlor Debbie A, Folsom Aaron R, Hoogeveen Ron, Reiner Alex, Keating Brendan, Day Ian N M

Abstract excerpt

Gallbladder disease (GBD) has an overall prevalence of 10-40% depending on factors such as age, gender, population, obesity and diabetes, and represents a major economic burden. Although gallstones are composed of cholesterol by-products and are associated with obesity, presumed causal pathways remain unproven, although BMI reduction is typically recommended. We performed genetic studies to discover candidate...

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PMID: 25920552
DOI: 10.1038/ejhg.2015.63
PMCID: PMC4681116

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ABCG5
ABCG8
GCKR

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