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Article

Up-Regulation of DNA Damage Response Signaling in Autosomal Dominant Polycystic Kidney Disease.

The American journal of pathology - 1 May 2021

Zhang Jennifer Q J, Saravanabavan Sayanthooran, Chandra Ashley N, Munt Alexandra, Wong Annette T Y, Harris Peter C, Harris David C H, McKenzie Paul, Wang Yiping, Rangan Gopala K

Abstract excerpt

DNA damage and alterations in DNA damage response (DDR) signaling could be one of the molecular mechanisms mediating focal kidney cyst formation in autosomal dominant polycystic kidney disease (ADPKD). The aim of this study was to test the hypothesis that markers of DNA damage and DDR signaling are increased in human and experimental ADPKD. In the human ADPKD transcriptome, the number of up-regulated DDR-related...

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Cysts
DNA Damage
Dogs
Epithelial Cells
Hydrogen Peroxide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polycystic Kidney, Autosomal Dominant

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PMID: 33549515
DOI: 10.1016/j.ajpath.2021.01.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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