Article
Integrating pathway analysis and genetics of gene expression for genome-wide association study of basal cell carcinoma.
Human genetics - 1 Apr 2012
Zhang Mingfeng, Liang Liming, Morar Nilesh, Dixon Anna L, Lathrop G Mark, Ding Jun, Moffatt Miriam F, Cookson William O C, Kraft Peter, Qureshi Abrar A, Han Jiali
Abstract excerpt
Genome-wide association studies (GWASs) have primarily focused on marginal effects for individual markers and have incorporated external functional information only after identifying robust statistical associations. We applied a new approach combining the genetics of gene expression and functional classification of genes to the GWAS of basal cell carcinoma (BCC) to identify potential biological pathways...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.