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Article

Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.

PloS one - 1 Jan 2017

Sebastian Aimy, Hum Nicholas R, Murugesh Deepa K, Hatsell Sarah, Economides Aris N, Loots Gabriela G

Abstract excerpt

Wnt3a is a major regulator of bone metabolism however, very few of its target genes are known in bone. Wnt3a preferentially signals through transmembrane receptors Frizzled and co-receptors Lrp5/6 to activate the canonical signaling pathway. Previous studies have shown that the canonical Wnt co-receptors Lrp5 and Lrp6 also play an essential role in normal postnatal bone homeostasis, yet, very little is known...

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Source

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Identifiers

PMID: 29176883
DOI: 10.1371/journal.pone.0188264
PMCID: PMC5703471

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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