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Oligoasthenoteratospermia and sperm tail bending in PPP4C-deficient mice

8 Dec 2020

Abstract excerpt

Protein phosphatase 4 (PPP4) is a protein phosphatase that, although highly expressed in the testis, currently has an unclear physiological role in this tissue. Here, we show that deletion of PPP4 catalytic subunit gene Ppp4c in the mouse causes male-specific infertility. Loss of PPP4C, when assessed by light microscopy, did not obviously affect many aspects of the morphology of spermatogenesis, including...

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PMID: 33543287
DOI: 10.1093/molehr/gaaa083

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