Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of Ppp1cc-Null Mice Suggests a Role for PP1gamma2 in Sperm Morphogenesis1

14 Feb 2007

Abstract excerpt

Serine/threonine protein phosphatase 1 (PP1) consists of four ubiquitously expressed major isoforms, two of which, PP1gamma1 and PP1gamma2, are derived by alternative splicing of a single gene, Ppp1cc. PP1gamma2 is the most abundant isoform in the testis, and is a key regulator of sperm motility. Targeted disruption of the Ppp1cc gene causes male infertility in mice due to impaired spermiogenesis. This study was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17301292
DOI: 10.1095/biolreprod.106.058610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of Ppp1cc-Null Mice Suggests a Role for PP1gamma2 in Sperm Morphogenesis1PMID 17301292Read ↗

Selective Ablation of Ppp1cc Gene in Testicular Germ Cells Causes Oligo-Teratozoospermia and Infertility in Mice1Semantic proximity Read ↗

The protein phosphatase isoform PP1γ1 substitutes for PP1γ2 to support spermatogenesis but not normal sperm function and fertility†Semantic proximity Read ↗

Loss of protein phosphatase 1c{gamma} (PPP1CC) leads to impaired spermatogenesis associated with defects in chromatin condensation and acrosome development: an ultrastructural analysis.Semantic proximity Read ↗

Significant expression levels of transgenic PPP1CC2 in testis and sperm are required to overcome the male infertility phenotype of Ppp1cc null mice.Semantic proximity Read ↗

Protein phosphatase PP1?2 in sperm morphogenesis and epididymal initiation of sperm motilitySemantic proximity Read ↗

Oligoasthenoteratospermia and sperm tail bending in PPP4C-deficient miceSemantic proximity Read ↗

Protein phosphatase 1 complexes modulate sperm motility and present novel targets for male infertilitySemantic proximity Read ↗

Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis.Semantic proximity Read ↗

Protein Phosphatase 4 (PPP4) Prevents Female Reprogramming in the Mouse Testis After Sex Determination and Protects Male FertilitySemantic proximity Read ↗

Scaffold Subunit Aalpha of PP2A Is Essential for Female Meiosis and Fertility in Mice1Semantic proximity Read ↗

PLAG1 deficiency impairs spermatogenesis and sperm motility in miceSemantic proximity Read ↗

Signaling Enzymes Required for Sperm Maturation and Fertilization in MammalsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.