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Cell-free tumour DNA analysis detects copy number alterations in gastro-oesophageal cancer patients

4 Feb 2021

Abstract excerpt

BACKGROUND: Analysis of cell-free tumour DNA, a liquid biopsy, is a promising biomarker for cancer. We have performed a proof-of principle study to test the applicability in the clinical setting, analysing copy number alterations (CNAs) in plasma and tumour tissue from 44 patients with gastro-oesophageal cancer. METHODS: DNA was isolated from blood plasma and a tissue sample from each patient. Array-CGH was...

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PMID: 33539436
DOI: 10.1371/journal.pone.0245488

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