Article

Pan-oesophageal and spatially resolved genetic analysis reveals instability signature for earlier diagnosis of squamous cell cancer

2025-11-30

Abstract excerpt

<h4>ABSTRACT</h4> Early detection of oesophageal squamous cell carcinoma (OSCC) significantly improves patients’ survival. Nonetheless, the availability of non-endoscopic, effective, and minimally invasive diagnostic approaches is limited. Here, we evaluated the utility of minimally invasive pan-oesophageal sampling using a capsule-sponge and aneuploidy detection using shallow whole genome sequencing (sWGS) for e...

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Literature Corpus work: 36cd856a-2ea1-5c82-9c85-9cd532264233
DOI: 10.1101/2025.11.27.25340016

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