Article
Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups.
Nature communications - 3 Feb 2021
Wang Yong-Fei, Zhang Yan, Lin Zhiming, Zhang Huoru, Wang Ting-You, Cao Yujie, Morris David L, Sheng Yujun, Yin Xianyong, Zhong Shi-Long, Gu Xiaoqiong, Lei Yao, He Jing, Wu Qi, Shen Jiangshan Jane, Yang Jing, Lam Tai-Hing, Lin Jia-Huang, Mai Zhi-Ming, Guo Mengbiao, Tang Yuanjia, Chen Yanhui, Song Qin, Ban Bo, Mok Chi Chiu, Cui Yong, Lu Liangjing, Shen Nan, Sham Pak C, Lau Chak Sing, Smith David K, Vyse Timothy J, Zhang Xuejun, Lau Yu Lung, Yang Wanling
Abstract excerpt
Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high heritability, shows differences in prevalence, severity and age of onset among different ancestral groups. Previous genetic studies have focused more on European populations, which appear to be the least affected. Consequently, the genetic variations that underlie the commonalities, differences and treatment options in SLE among...
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