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Article

Genetic Evidence for SecY Translocon-Mediated Import of Two Contact-Dependent Growth Inhibition (CDI) Toxins.

mBio - 2 Feb 2021

Jones Allison M, Virtanen Petra, Hammarlöf Disa, Allen William J, Collinson Ian, Hayes Christopher S, Low David A, Koskiniemi Sanna

Abstract excerpt

The C-terminal (CT) toxin domains of contact-dependent growth inhibition (CDI) CdiA proteins target Gram-negative bacteria and must breach both the outer and inner membranes of target cells to exert growth inhibitory activity. Here, we examine two CdiA-CT toxins that exploit the bacterial general protein secretion machinery after delivery into the periplasm. A Ser281Phe amino acid substitution in transmembrane...

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Identifiers

PMID: 33531386
DOI: 10.1128/mBio.03367-20
PMCID: PMC7858069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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