Article
Evaluation of the Oncomine Pan-Cancer Cell-Free Assay for Analyzing Circulating Tumor DNA in the Cerebrospinal Fluid in Patients with Central Nervous System Malignancies.
The Journal of molecular diagnostics : JMD - 1 Feb 2021
Shah Mauli, Takayasu Takeshi, Zorofchian Moghadamtousi Soheil, Arevalo Octavio, Chen Melissa, Lan Chieh, Duose Dzifa, Hu Peter, Zhu Jay-Jiguang, Roy-Chowdhuri Sinchita, Riascos Roy F, Chen Hui, Luthra Rajyalakshmi, Esquenazi Yoshua, Ballester Leomar Y
Abstract excerpt
Available tools to evaluate patients with central nervous system (CNS) tumors such as magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) cytology, and brain biopsies, have significant limitations. MRI and CSF cytology have poor specificity and sensitivity, respectively, and brain biopsies are invasive. Circulating tumor DNA in CSF (CSF-ctDNA) could be used as a biomarker in patients with CNS tumors, but...
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