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Article

Multiple myeloma in the marrow: pathogenesis and treatments.

Annals of the New York Academy of Sciences - 1 Jan 2016

Fairfield Heather, Falank Carolyne, Avery Lindsey, Reagan Michaela R

Abstract excerpt

Multiple myeloma (MM) is a B cell malignancy resulting in osteolytic lesions and fractures. In the disease state, bone healing is limited owing to increased osteoclastic and decreased osteoblastic activity, as well as an MM-induced forward-feedback cycle where bone-embedded growth factors further enhance tumor progression as bone is resorbed. Recent work on somatic mutation in MM tumors has provided insight into...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27002787
DOI: 10.1111/nyas.13038
PMCID: PMC4806534

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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