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Article

Effects of CREG1 on Age-Associated Metabolic Phenotypes and Renal Senescence in Mice.

International journal of molecular sciences - 28 Jan 2021

Hashimoto Michihiro, Goto Ayumi, Endo Yuki, Sugimoto Masataka, Ueda Jun, Yamashita Hitoshi

Abstract excerpt

Cellular repressor of E1A-stimulated genes 1 (CREG1) is a secreted glycoprotein that accelerates p16-dependent cellular senescence in vitro. We recently reported the ability of CREG1 to stimulate brown adipogenesis using adipocyte P2-CREG1-transgenic (Tg) mice; however, little is known about the effect of CREG1 on aging-associated phenotypes. In this study, we investigated the effects of CREG1 on age-related...

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Identifiers

PMID: 33525404
DOI: 10.3390/ijms22031276
PMCID: PMC7866020

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