Article
Tau modulation through AAV9 therapy augments Akt/Erk survival signalling in glaucoma mitigating the retinal degenerative phenotype.
Acta neuropathologica communications - 7 Jun 2024
Thananthirige Kanishka Pushpitha Maha, Chitranshi Nitin, Basavarajappa Devaraj, Rajput Rashi, Abbasi Mojdeh, Palanivel Viswanthram, Gupta Veer Bala, Paulo Joao A, Koronyo-Hamaoui Maya, Mirzaei Mehdi, Graham Stuart L, Gupta Vivek
Abstract excerpt
The microtubule-associated protein Tau is a key player in various neurodegenerative conditions, including Alzheimer's disease (AD) and Tauopathies, where its hyperphosphorylation disrupts neuronal microtubular lattice stability. Glaucoma, a neurodegenerative disorder affecting the retina, leads to irreversible vision loss by damaging retinal ganglion cells and the optic nerve, often associated with increased...
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