Frequent genetic alterations in immune checkpoint-related genes in intravascular large B-cell lymphoma.

doi:10.1182/blood.2020007245

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Article

Frequent genetic alterations in immune checkpoint-related genes in intravascular large B-cell lymphoma.

Blood - 18 Mar 2021

Shimada Kazuyuki, Yoshida Kenichi, Suzuki Yasuhiro, Iriyama Chisako, Inoue Yoshikage, Sanada Masashi, Kataoka Keisuke, Yuge Masaaki, Takagi Yusuke, Kusumoto Shigeru, Masaki Yasufumi, Ito Takahiko, Inagaki Yuichiro, Okamoto Akinao, Kuwatsuka Yachiyo, Nakatochi Masahiro, Shimada Satoko, Miyoshi Hiroaki, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Shiozawa Yusuke, Nannya Yasuhito, Okabe Asako, Kohno Kei, Atsuta Yoshiko, Ohshima Koichi, Nakamura Shigeo, Ogawa Seishi, Tomita Akihiro, Kiyoi Hitoshi

Abstract excerpt

Intravascular large B-cell lymphoma (IVLBCL) is a unique type of extranodal lymphoma characterized by selective growth of tumor cells in small vessels without lymphadenopathy. Greater understanding of the molecular pathogenesis of IVLBCL is hampered by the paucity of lymphoma cells in biopsy specimens, creating a limitation in obtaining sufficient tumor materials. To uncover the genetic landscape of IVLBCL, we...

Topics

Aged
Aged, 80 and over
Animals
B7-H1 Antigen
Cell-Free Nucleic Acids
Female
Gene Expression Regulation, Neoplastic
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma, Large B-Cell, Diffuse

Male

Middle Aged

Mutation

Programmed Cell Death 1 Ligand 2 Protein

Programmed Cell Death 1 Receptor

Tumor Escape

Vascular Neoplasms

Exome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 33512416
DOI: 10.1182/blood.2020007245
PMCID: PMC7976508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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