Article
Genomic Analyses Identify Recurrent Alterations in Immune Evasion Genes in Diffuse Large B-Cell Lymphoma, Leg Type.
The Journal of investigative dermatology - 1 Nov 2018
Zhou Xiaolong Alan, Louissaint Abner, Wenzel Alexander, Yang Jingyi, Martinez-Escala Maria Estela, Moy Andrea P, Morgan Elizabeth A, Paxton Christian N, Hong Bo, Andersen Erica F, Guitart Joan, Behdad Amir, Cerroni Lorenzo, Weinstock David M, Choi Jaehyuk
Abstract excerpt
Cutaneous diffuse large B-cell lymphomas (DLBCLs) are aggressive lymphomas with a poor prognosis. To elucidate their genetic bases, we analyzed exome sequencing of 37 cutaneous DLBCLs, including 31 DLBCLs, leg type (DLBCL-LT) and 6 cutaneous DLBCLs-not otherwise specified (DLBCL-NOS). As reported previously, 77% of DLBCL-LT harbor NF-κB-activating MYD88 mutations. In nearly all MYD88-wild-type DLBCL-LT, we found...
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