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Article

Plasma circulating tumour DNA is a better source for diagnosis and mutational analysis of IVLBCL than tissue DNA.

Journal of cellular and molecular medicine - 1 Jul 2024

Chen Chao, Di Yiao, Zhuang Zhe, Cai Hao, Jia Congwei, Wang Wei, Zhao Danqing, Wei Chong, Zhang Wei, Zhou Daobin, Zhang Yan

Abstract excerpt

Diagnosis of intravascular large B-cell lymphoma (IVLBCL) is a challenge due to its heterogeneous clinical presentation and lack of specific markers. This retrospective study investigated the utility of circulating tumour DNA (ctDNA) sequencing for diagnosing IVLBCL and analysing its mutation landscape. A cohort of 34 IVLBCL patients enrolled and underwent plasma ctDNA targeted sequencing. The median plasma ctDNA...

Topics

Humans
Circulating Tumor DNA
Female
Male
Middle Aged
Aged
Mutation
Lymphoma, Large B-Cell, Diffuse
DNA Mutational Analysis
Biomarkers, Tumor
Adult

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Retrospective Studies

Aged, 80 and over

Source

Open in PubMed Open full text

Identifiers

PMID: 39054569
DOI: 10.1111/jcmm.18576
PMCID: PMC11272604

Genes

B2M
BCL6
CD58
CD79B
MYD88
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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