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Article

Psoriatic arthritis subtypes are phenocopied in humanized mice.

JCI insight - 2 Jul 2024

Ritchlin Christopher T, Rangel-Moreno Javier, Martino Delaney, Isett Brian, Paine Ananta, Bhattacharya Soumyaroop, Fox Jeffrey, Meyer Ernest M, Bao Riyue, Bruno Tullia, Tausk Francisco, de la Luz Garcia-Hernandez Maria

Abstract excerpt

Psoriatic arthritis (PsA) is a complex inflammatory disease that challenges diagnosis and complicates the rational selection of effective therapies. Although T cells are considered active effectors in psoriasis and PsA, the role of CD8+ T cells in pathogenesis is not well understood. We selected the humanized mouse model NSG-SGM3 transgenic strain to examine psoriasis and PsA endotypes. Injection of PBMCs and...

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Topics

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Share to Arthritis, Psoriatic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39114979
DOI: 10.1172/jci.insight.178213
PMCID: PMC11383598

Genes

CXCL14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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