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Article

The Novel Membrane-Associated Auxiliary Factors AuxA and AuxB Modulate β-lactam Resistance in MRSA by stabilizing Lipoteichoic Acids.

International journal of antimicrobial agents - 1 Mar 2021

Mikkelsen Kasper, Sirisarn Wanchat, Alharbi Ohood, Alharbi Mohanned, Liu Huayong, Nøhr-Meldgaard Katrine, Mayer Katharina, Vestergaard Martin, Gallagher Laura A, Derrick Jeremy P, McBain Andrew J, Biboy Jacob, Vollmer Waldemar, O'Gara James P, Grunert Tom, Ingmer Hanne, Xia Guoqing

Abstract excerpt

A major determinant of β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) is the drug insensitive transpeptidase, PBP2a, encoded by mecA. Full expression of the resistance phenotype requires auxiliary factors. Two such factors, auxiliary factor A (auxA, SAUSA300_0980) and B (auxB, SAUSA300_1003), were identified in a screen against mutants with increased susceptibility to β-lactams in the...

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PMID: 33503451
DOI: 10.1016/j.ijantimicag.2021.106283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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