Article
Old Drugs To Treat Resistant Bugs: Methicillin-Resistant Staphylococcus aureus Isolates with mecC Are Susceptible to a Combination of Penicillin and Clavulanic Acid.
Antimicrobial agents and chemotherapy - 1 Dec 2015
Ba Xiaoliang, Harrison Ewan M, Lovering Andrew L, Gleadall Nicholas, Zadoks Ruth, Parkhill Julian, Peacock Sharon J, Holden Matthew T G, Paterson Gavin K, Holmes Mark A
Abstract excerpt
β-Lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) is mediated by the expression of an alternative penicillin-binding protein 2a (PBP2a) (encoded by mecA) with a low affinity for β-lactam antibiotics. Recently, a novel variant of mecA, known as mecC, was identified in MRSA isolates from both humans and animals. In this study, we demonstrate that mecC-encoded PBP2c does not mediate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.