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Article

In Vivo Functional Effects of CYP2C9 M1L, a Novel and Common Variant in the Yup'ik Alaska Native Population.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2021

Henderson Lindsay M, Hopkins Scarlett E, Boyer Bert B, Thornton Timothy A, Rettie Allan E, Thummel Kenneth E

Abstract excerpt

Alaska Native people are under-represented in genetic research but have unique gene variation that may critically impact their response to pharmacotherapy. Full resequencing of CYP2C9 in a cross-section of this population identified CYP2C9 Met1Leu (M1L), a novel, relatively common single nucleotide polymorphism hypothesized to confer CYP2C9 poor metabolizer phenotype by disrupting the start codon. M1L is present...

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Identifiers

PMID: 33632714
DOI: 10.1124/dmd.120.000301
PMCID: PMC8008381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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