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Article

Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark.

Diabetologia - 1 Apr 2021

de Almeida-Faria Juliana, Duque-Guimarães Daniella E, Ong Thomas P, Pantaleão Lucas C, Carpenter Asha A, Loche Elena, Kusinski Laura C, Ashmore Thomas J, Antrobus Robin, Bushell Martin, Fernandez-Twinn Denise S, Ozanne Susan E

Abstract excerpt

AIMS/HYPOTHESIS: Levels of the microRNA (miRNA) miR-126-3p are programmed cell-autonomously in visceral adipose tissue of adult offspring born to obese female C57BL/6J mice. The spectrum of miR-126-3p targets and thus the consequences of its dysregulation for adipocyte metabolism are unknown. Therefore, the aim of the current study was to identify novel targets of miR-126-3p in vitro and then establish the...

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Share to 3T3-L1 Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33501603
DOI: 10.1007/s00125-020-05357-4
PMCID: PMC7940301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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