Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance.

doi:10.1016/j.celrep.2018.01.074

Article

Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance.

Cell reports - 20 Feb 2018

Price Nathan L, Singh Abhishek K, Rotllan Noemi, Goedeke Leigh, Wing Allison, Canfrán-Duque Alberto, Diaz-Ruiz Alberto, Araldi Elisa, Baldán Ángel, Camporez Joao-Paulo, Suárez Yajaira, Rodeheffer Matthew S, Shulman Gerald I, de Cabo Rafael, Fernández-Hernando Carlos

Abstract excerpt

While therapeutic modulation of miRNAs provides a promising approach for numerous diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target effects. miR-33 has emerged as a likely target for treatment of cardiovascular diseases. However, the deleterious effects of long-term anti-miR-33 therapies and predisposition of miR-33-/- mice to obesity and metabolic dysfunction exemplify the...

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Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance.

Abstract excerpt

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