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Article

Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes

6 Jan 2012

Abstract excerpt

Nutrition during early mammalian development permanently influences health of the adult, including increasing the risk of type 2 diabetes and coronary heart disease. However, the molecular mechanisms underlying such programming are poorly defined. Here we demonstrate that programmed changes in miRNA expression link early-life nutrition to long-term health. Specifically, we show that miR-483-3p is upregulated in...

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PMID: 22223106
DOI: 10.1038/cdd.2011.183

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