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Article

Short Communication: HIV-1 Drug Resistance Mutation Analyses of Cameroon-Derived Integrase Sequences.

AIDS research and human retroviruses - 1 Jan 2021

Mikasi Sello Given, Isaacs Darren, Ikomey George Mondinde, Shimba Henerico, Cloete Ruben, Jacobs Graeme Brendon

Abstract excerpt

HIV-1 integrase (IN) is a primary target for combination antiretroviral therapy. Only a limited number of studies report on the emergence of resistance-associated mutations (RAMs) in Cameroon. We observed that 1.4% of sequence from treatment-naive patients had IN strand transfer inhibitor (INSTI) RAMs. These mutations confer resistance to raltegravir and elvitegravir. We also observed that 10.1% of the sequences...

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Identifiers

PMID: 32640829
DOI: 10.1089/AID.2020.0022

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