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Article

Variability in HIV-1 Integrase Gene and 3'-Polypurine Tract Sequences in Cameroon Clinical Isolates, and Implications for Integrase Inhibitors Efficacy.

International journal of molecular sciences - 25 Feb 2020

Acharya Arpan, Tagny Claude T, Mbanya Dora, Fonsah Julius Y, Nchindap Emilienne, Kenmogne Léopoldine, Jihyun Ma, Njamnshi Alfred K, Kanmogne Georgette D

Abstract excerpt

: Integrase strand-transfer inhibitors (INSTIs) are now included in preferred first-line antiretroviral therapy (ART) for HIV-infected adults. Studies of Western clade-B HIV-1 show increased resistance to INSTIs following mutations in integrase and nef 3'polypurine tract (3'-PPT). With anticipated shifts in Africa (where 25.6-million HIV-infected people resides) to INSTIs-based ART, it is critical to monitor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Identifiers

PMID: 32106437
DOI: 10.3390/ijms21051553
PMCID: PMC7084836

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