Article

Dual Role of Neuroplastin in Pancreatic β Cells: Regulating Insulin Secretion and Promoting Islet Inflammation

2023-09-08

Abstract excerpt

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-resident secretory protein that reduces inflammation and promotes proliferation in pancreatic β cells. Numerous studies have highlighted the potential of MANF as a therapeutic agent for diabetes mellitus (DM), making it essential to understand the mechanisms underlying MANF’s functions. In our previous search for a molecule...

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Literature Corpus work: 66095465-8d83-503a-9e4a-1e9612312be8
DOI: 10.1101/2023.09.08.556759

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