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Article

The protective role of mesencephalic astrocyte-derived neurotrophic factor in endoplasmic reticulum stress in RT4-D6P2T schwannoma sells with the S63del MPZ mutation.

Frontiers in bioscience (Landmark edition) - 4 Jan 2022

Sun Bo, Wang Hongfen, Li Yanran, He Zhengqing, Cui Fang, Yang Fei, Huang Xusheng

Abstract excerpt

BACKGROUND: Endoplasmic reticulum stress (ERS) occurred in S63del mutant CMT1B mice model, and few drugs has been studied. Mesencephalic astrocyte-derived neurotrophic factor (MANF) can inhibit ERS. This study aimed at investigating the effect of MANF on ERS of RT4-D6P2T schwannoma cells with S63del MPZ Mutation. METHODS: Experimental grouping: blank control group, blank control + MANF group, lentivirus group,...

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PMID: 35090307
DOI: 10.31083/j.fbl2701001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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