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Article

Adult mouse eIF2Bε Arg191His astrocytes display a normal integrated stress response in vitro.

Scientific reports - 28 Feb 2018

Wisse Lisanne E, Ter Braak Timo J, van de Beek Malu-Clair, van Berkel Carola G M, Wortel Joke, Heine Vivi M, Proud Chris G, van der Knaap Marjo S, Abbink Truus E M

Abstract excerpt

Vanishing white matter (VWM) is a genetic childhood white matter disorder, characterized by chronic as well as episodic, stress provoked, neurological deterioration. Treatment is unavailable and patients often die within a few years after onset. VWM is caused by recessive mutations in the eukaryotic initiation factor 2B (eIF2B). eIF2B regulates protein synthesis rates in every cell of the body. In normal cells,...

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Identifiers

PMID: 29491431
DOI: 10.1038/s41598-018-21885-x
PMCID: PMC5830650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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