Article

Gene supplementation in Vanishing White Matter mice ameliorates the disease

2025-12-09

Abstract excerpt

Vanishing White Matter is a leukodystrophy associated with neurological decline, including motor deficits, and premature death. It is caused by mutations in the genes encoding the subunits of eukaryotic Translation Initiation Factor 2B (eIF2B), leading to constitutive activation of the Integrated Stress Response, especially in astrocytes. Brain pathology shows immature and dysfunctional glia in the central nervous...

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Literature Corpus work: 5a893656-88ee-5fa8-a950-3dc1d25b15eb
DOI: 10.64898/2025.12.05.692143

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