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Article

Mechanistic basis of propofol-induced disruption of kinesin processivity.

Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2021

Dutta Mandira, Gilbert Susan P, Onuchic José N, Jana Biman

Abstract excerpt

Propofol is a widely used general anesthetic to induce and maintain anesthesia, and its effects are thought to occur through impact on the ligand-gated channels including the GABAA receptor. Propofol also interacts with a large number of proteins including molecular motors and inhibits kinesin processivity, resulting in significant decrease in the run length for conventional kinesin-1 and kinesin-2. However, the...

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Identifiers

PMID: 33495322
DOI: 10.1073/pnas.2023659118
PMCID: PMC7865149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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