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Article

De novo adult acute myeloid leukemia with two new mutations in juxtatransmembrane domain of the FLT3 gene: a case report.

Journal of medical case reports - 26 Jan 2021

Alarbeed Ismael F, Wafa Abdulsamad, Moassass Faten, Al-Halabi Bassel, Al-Achkar Walid, Liehr Thomas, Aboukhamis Imad

Abstract excerpt

BACKGROUND: Approximately 30% of adult acute myeloid leukemia (AML) acquire within fms-like tyrosine kinase 3 gene (FLT3) internal tandem duplications (FLT3/ITDs) in their juxtamembrane domain (JMD). FLT3/ITDs range in size from three to hundreds of nucleotides, and confer an adverse prognosis. Studies on a possible relationship between of FLT3/ITDs length and clinical outcomes in those AML patients were...

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Identifiers

PMID: 33494808
DOI: 10.1186/s13256-020-02587-3
PMCID: PMC7836474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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