Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

No observed effect on brain vasculature of Alzheimer's disease-related mutations in the zebrafish presenilin 1 gene.

Molecular brain - 25 Jan 2021

Barthelson Karissa, Newman Morgan, Nowell Cameron J, Lardelli Michael

Abstract excerpt

Previously, we found that brains of adult zebrafish heterozygous for Alzheimer's disease-related mutations in their presenilin 1 gene (psen1, orthologous to human PSEN1) show greater basal expression levels of hypoxia responsive genes relative to their wild type siblings under normoxia, suggesting hypoxic stress. In this study, we investigated whether this might be due to changes in brain vasculature. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Brain
Share to Green Fluorescent Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterozygote

Share to Mutation

Share to Presenilin-1

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 33494778
DOI: 10.1186/s13041-021-00734-5
PMCID: PMC7831246

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No observed effect on brain vasculature of Alzheimer's disease-related mutations in the zebrafish presenilin 1 gene.PMID 33494778Read ↗

Accelerated loss of hypoxia response in zebrafish with familial Alzheimer’s disease-like mutation of Presenilin 1Semantic proximity Read ↗

Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of presenilin 1.Semantic proximity Read ↗

Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations.Semantic proximity Read ↗

Skeletal and CNS defects in Presenilin-1-deficient mice.Semantic proximity Read ↗

Mural cells protect the adult brain from hemorrhage but do not control the blood-brain barrier in developing zebrafishSemantic proximity Read ↗

Analysis of the vasculature by immunohistochemistry in paraffin-embedded brains.Semantic proximity Read ↗

Presenilin-1-associated abnormalities in regional cerebral perfusion.Semantic proximity Read ↗

Age-related impairment of cerebral blood flow response to KATP channel opener in Alzheimer's disease mice with presenilin-1 mutation.Semantic proximity Read ↗

Aquaporins enriched in endothelial vacuole membrane regulate the diameters of microvasculature in hyperglycemiaSemantic proximity Read ↗

Notch receptor expression in human brain arteriovenous malformationsSemantic proximity Read ↗

Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development.Semantic proximity Read ↗

CNS angiogenesis and barriergenesis occur simultaneously.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.