Article
Gene-environment interactions: key to unraveling the mystery of Parkinson's disease.
Progress in neurobiology - 1 Jun 2011
Gao Hui-Ming, Hong Jau-Shyong
Abstract excerpt
Parkinson's disease (PD) is the second most common neurodegenerative disease. The gradual, irreversible loss of dopamine neurons in the substantia nigra is the signature lesion of PD. Clinical symptoms of PD become apparent when 50-60% of nigral dopamine neurons are lost. PD progresses insidiously for 5-7 years (preclinical period) and then continues to worsen even under the symptomatic treatment. To determine...
Topics
- Animals
- Disease Models, Animal
- Environment
- Genetic Predisposition to Disease
- Humans
- Parkinson Disease