Article
Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes.
Cell stem cell - 2 Jun 2016
Yamada Mitsutoshi, Emmanuele Valentina, Sanchez-Quintero Maria J, Sun Bruce, Lallos Gregory, Paull Daniel, Zimmer Matthew, Pagett Shardonay, Prosser Robert W, Sauer Mark V, Hirano Michio, Egli Dieter
Abstract excerpt
Replacement of mitochondria through nuclear transfer between oocytes of two different women has emerged recently as a strategy for preventing inheritance of mtDNA diseases. Although experiments in human oocytes have shown effective replacement, the consequences of small amounts of mtDNA carryover have not been studied sufficiently. Using human mitochondrial replacement stem cell lines, we show that, even though...
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