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Article

Assessing the clinical utility of genetic risk scores for targeted cancer screening.

Journal of translational medicine - 22 Jan 2021

Conran Carly A, Shi Zhuqing, Resurreccion William Kyle, Na Rong, Helfand Brian T, Genova Elena, Zheng Siqun Lilly, Brendler Charles B, Xu Jianfeng

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified thousands of disease-associated single nucleotide polymorphisms (SNPs). A subset of these SNPs may be additively combined to generate genetic risk scores (GRSs) that confer risk for a specific disease. Although the clinical validity of GRSs to predict risk of specific diseases has been well established, there is still a great need to determine their...

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Identifiers

PMID: 33482857
DOI: 10.1186/s12967-020-02699-w
PMCID: PMC7821544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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