Article
Association between tobacco substance usage and a missense mutation in the tumor suppressor gene P53 in the Saudi Arabian population.
PloS one - 1 Jan 2021
Almutairi Mikhlid H, Almutairi Bader O, Alrubie Turki M, Alharbi Sultan N, Parine Narasimha R, Alrefaei Abdulwahed F, Aldeailej Ibrahim, Alamri Abdullah, Semlali Abdelhabib
Abstract excerpt
The tumor suppressor gene TP53 and its downstream genes P21 and MDM2 play crucial roles in combating DNA damage at the G1/S cell cycle checkpoint. Polymorphisms in these genes can lead to the development of various diseases. This study was conducted to examine a potential association between tobacco substance usage (TSU) and single-nucleotide polymorphism (SNP) at the exon regions of the P53, P21, and MDM2 genes...
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