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Article

Interaction between tumour necrosis factor-α gene polymorphisms and substance use on risk of betel quid-related oral and pharyngeal squamous cell carcinoma in Taiwan.

Archives of oral biology - 1 Oct 2011

Yang Cheng-Mei, Hou Yu-Yi, Chiu Yi-Ten, Chen Hung-Chih, Chu Sau-Tung, Chi Chao-Chuan, Hsiao Michael, Lee Chien-Yiing, Hsieh Christina Jen-Chia, Lin Yu-Chen, Hsieh Yao-Dung, Ger Luo-Ping

Abstract excerpt

OBJECTIVE: Betel quid (BQ) components induce the secretion of tumour necrosis factor-alpha (TNF-α) in oral keratinocytes, which promotes oral mucosal inflammation and oral cancer. This study was carried out to evaluate the association of TNFA genetic variants (-308G>A and -238G>A) with the risk and prognosis of BQ-related oral and pharyngeal squamous cell carcinoma (OPSCC). DESIGN: A total of 403 subjects (205...

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PMID: 21497332
DOI: 10.1016/j.archoralbio.2011.03.009

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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