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Diseases Associated with Mutation of Replication and Repair Proteins.

Advances in experimental medicine and biology - 1 Jan 2000

Cotterill Sue

Abstract excerpt

Alterations in proteins that function in DNA replication and repair have been implicated in the development of human diseases including cancer, premature ageing, skeletal disorders, mental retardation, microcephaly, and neurodegeneration. Drosophila has orthologues of most human replication and repair proteins and high conservation of the relevant cellular pathways, thus providing a versatile system in which to...

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PMID: 29951822
DOI: 10.1007/978-981-13-0529-0_12

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