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Article

Mechanisms and pathways of growth failure in primordial dwarfism.

Genes & development - 1 Oct 2011

Klingseisen Anna, Jackson Andrew P

Abstract excerpt

The greatest difference between species is size; however, the developmental mechanisms determining organism growth remain poorly understood. Primordial dwarfism is a group of human single-gene disorders with extreme global growth failure (which includes Seckel syndrome, microcephalic osteodysplastic primordial dwarfism I [MOPD] types I and II, and Meier-Gorlin syndrome). Ten genes have now been identified for...

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Identifiers

PMID: 21979914
DOI: 10.1101/gad.169037
PMCID: PMC3197200

Genes

ATR
CDC6
CDT1
CPAP
ORC1
ORC4
ORC6
PCNT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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