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Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma

20 Jan 2021

Abstract excerpt

Mucoepidermoid carcinoma (MEC) is the most common type of salivary gland cancers and patients with advanced, metastatic, and recurrent MECs have limited therapeutic options and poor treatment outcomes. MEC is commonly associated with a chromosomal translocation t(11;19) (q14-21;p12-13) that encodes the CRTC1-MAML2 oncogenic fusion. The CRTC1-MAML2 fusion is required for MEC growth in part through inducing...

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PMID: 33473104
DOI: 10.1038/s41392-020-00388-0

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