Salivary Gland Cancer Patient-Derived Xenografts Enable Characterization of Cancer Stem Cells and New Gene Events Associated with Tumor Progression.

doi:10.1158/1078-0432.CCR-17-3871

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Article

Salivary Gland Cancer Patient-Derived Xenografts Enable Characterization of Cancer Stem Cells and New Gene Events Associated with Tumor Progression.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2018

Keysar Stephen B, Eagles Justin R, Miller Bettina, Jackson Brian C, Chowdhury Farshad N, Reisinger Julie, Chimed Tugs-Saikhan, Le Phuong N, Morton John J, Somerset Hilary L, Varella-Garcia Marileila, Tan Aik-Choon, Song John I, Bowles Daniel W, Reyland Mary E, Jimeno Antonio

Abstract excerpt

Purpose: Salivary gland cancers (SGC) frequently present with distant metastases many years after diagnosis, suggesting a cancer stem cell (CSC) subpopulation that initiates late recurrences; however, current models are limited both in their availability and suitability to characterize these rare cells.Experimental Design: Patient-derived xenografts (PDX) were generated by engrafting patient tissue onto nude mice...

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Identifiers

PMID: 29555661
DOI: 10.1158/1078-0432.CCR-17-3871
PMCID: PMC6004240

Genes

NFIB
ETV6
MTFR2
MYB
MYC
NTRK3
SIK1
SOX2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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